| Date | H/A | W/L | Team | Score | Opponent | Score | ||
| 2021-09-02 | H | L | Blacksburg (VA) | 6 | Lord Botetourt (VA) (5) | 42 | Hx 1060 | |
| 2021-09-10 | H | L | Blacksburg (VA) | 19 | Grundy (VA) (4) | 20 | Hx 1173 | |
| 2021-10-08 | A | L | Blacksburg (VA) | 0 | Christiansburg (VA) (1) | 63 | Hx 1209 | |
| 2021-10-15 | H | L | Blacksburg (VA) | 7 | Pulaski County (VA) (4) | 49 | Hx 1082 | |
| 2021-10-28 | A | L | Blacksburg (VA) | 7 | Graham (VA) (9) | 46 | Hx 1027 | |
| 2021-11-02 | H | L | Blacksburg (VA) | 0 | Salem (VA) (9) | 1 | Hx 1198 |