| Date | H/A | W/L | Team | Score | Opponent | Score | ||
| 2021-08-27 | H | W | Meadow Bridge | 26 | Van () | 14 | 549 | |
| 2021-09-10 | A | L | Meadow Bridge | 0 | Midland Trail () | 33 | 551 | |
| 2021-09-17 | A | L | Meadow Bridge | 12 | James Monroe () | 50 | 537 | |
| 2021-10-01 | H | L | Meadow Bridge | 12 | Greenbrier West () | 51 | 516 | |
| 2021-10-08 | H | W | Meadow Bridge | 42 | Webster County () | 14 | 552 | |
| 2021-10-15 | A | W | Meadow Bridge | 22 | Summers County () | 6 | 553 | |
| 2021-10-19 | A | L | Meadow Bridge | 18 | Richwood () | 22 | 550 | |
| 2021-10-22 | A | W | Meadow Bridge | 34 | Montcalm () | 0 | 555 | |
| 2021-10-29 | H | W | Meadow Bridge | 22 | Sherman () | 14 | 554 | |
| 2021-11-05 | H | W | Meadow Bridge | 24 | Gilmer County () | 14 | 512 | |
| 2021-11-13 | A | L | Meadow Bridge | 6 | East Hardy () | 45 | 3-14 1st RD | 1270 |