| Date | H/A | W/L | Team | Score | Opponent | Score | |||
| 2021-03-06 | A | W | Grafton | 77 | East Fairmont | 44 | 84 | ||
| 2021-03-11 | A | W | Grafton | 73 | Notre Dame | 66 | 475 | ||
| 2021-03-13 | A | W | Grafton | 82 | Gilmer County | 34 | 1064 | ||
| 2021-03-16 | A | L | Grafton | 69 | Bridgeport | 87 | 485 | ||
| 2021-03-18 | A | W | Grafton | 73 | Lewis County | 37 | 486 | ||
| 2021-03-20 | H | W | Grafton | 71 | Liberty-Harrison | 46 | 143 | ||
| 2021-03-23 | H | W | Grafton | 100 | Elkins | 47 | 144 | ||
| 2021-03-25 | H | W | Grafton | 87 | Preston | 70 | 145 | ||
| 2021-03-27 | A | W | Grafton | 72 | Philip Barbour | 68 | 487 | ||
| 2021-03-30 | A | L | Grafton | 51 | Fairmont Sr. | 78 | 115 | ||
| 2021-04-01 | H | W | Grafton | 61 | North Marion | 59 | 146 | ||
| 2021-04-03 | A | L | Grafton | 40 | Robert C. Byrd | 91 | 488 | ||
| 2021-04-07 | H | W | Grafton | 66 | Lincoln | 54 | 147 | ||
| 2021-04-09 | A | W | Grafton | 60 | Liberty-Harrison | 30 | 489 | ||
| 2021-04-12 | H | L | Grafton | 88 | Buckhannon-Upshur | 93 | 148 | ||
| 2021-04-21 | H | W | Grafton | 57 | Notre Dame | 55 | 1174 | ||
| 2021-04-23 | A | L | Grafton | 50 | Fairmont Sr. | 60 | 1239 | ||
| 2021-04-27 | A | L | Grafton | 66 | Robert C. Byrd | 84 | 1267 |