| Date | H/A | W/L | Team | Score | Opponent | Score | |||
| 2021-03-06 | A | W | Buckhannon-Upshur | 55 | Lincoln | 52 | 525 | ||
| 2021-03-09 | A | W | Buckhannon-Upshur | 77 | Preston | 57 | 750 | ||
| 2021-03-11 | H | L | Buckhannon-Upshur | 42 | Robert C. Byrd | 64 | 535 | ||
| 2021-03-13 | H | W | Buckhannon-Upshur | 65 | Parkersburg South | 62 | 1063 | ||
| 2021-03-15 | A | L | Buckhannon-Upshur | 64 | Morgantown | 82 | 993 | ||
| 2021-03-16 | H | W | Buckhannon-Upshur | 70 | Liberty-Harrison | 52 | 518 | ||
| 2021-03-18 | A | L | Buckhannon-Upshur | 59 | Fairmont Sr. | 74 | 112 | ||
| 2021-03-23 | A | W | Buckhannon-Upshur | 52 | East Fairmont | 41 | 87 | ||
| 2021-03-25 | A | W | Buckhannon-Upshur | 67 | Capital | 39 | 1077 | ||
| 2021-03-30 | A | L | Buckhannon-Upshur | 55 | University | 58 | 992 | ||
| 2021-04-01 | H | W | Buckhannon-Upshur | 70 | Philip Barbour | 54 | 991 | ||
| 2021-04-05 | H | W | Buckhannon-Upshur | 54 | Bridgeport | 49 | 923 | ||
| 2021-04-07 | A | W | Buckhannon-Upshur | 68 | Lewis County | 58 | 512 | ||
| 2021-04-09 | H | W | Buckhannon-Upshur | 82 | Elkins | 40 | 504 | ||
| 2021-04-12 | A | W | Buckhannon-Upshur | 93 | Grafton | 88 | 148 | ||
| 2021-04-15 | A | L | Buckhannon-Upshur | 62 | South Charleston | 68 | 1152 | ||
| 2021-04-17 | A | L | Buckhannon-Upshur | 82 | Jefferson | 86 | 1208 | ||
| 2021-04-20 | H | W | Buckhannon-Upshur | 63 | Bridgeport | 47 | 1159 | ||
| 2021-04-22 | A | L | Buckhannon-Upshur | 53 | University | 65 | 1226 | ||
| 2021-04-28 | A | L | Buckhannon-Upshur | 58 | Morgantown | 83 | 1249 |