| Date | H/A | W/L | Team | Score | Opponent | Score | ||
| 2021-08-27 | H | W | Clay-Battelle | 48 | Federal Hocking (OH) (0) | 0 | Hx 774 | |
| 2021-09-03 | H | L | Clay-Battelle | 12 | East Hardy (10) | 45 | Hx 486 | |
| 2021-09-10 | H | W | Clay-Battelle | 49 | Valley-Wetzel (3) | 8 | Hx 487 | |
| 2021-09-17 | H | W | Clay-Battelle | 50 | Beallsville (OH) (2) | 18 | Hx 404 | |
| 2021-09-24 | A | W | Clay-Battelle | 36 | Tygarts Valley (4) | 30 | Hx 488 | |
| 2021-10-01 | H | W | Clay-Battelle | 41 | Hancock (MD) (1) | 0 | Hx 405 | |
| 2021-10-08 | A | W | Clay-Battelle | 56 | Massanutten Mil. Acad. (VA) (0) | 0 | Hx 406 | |
| 2021-10-15 | A | L | Clay-Battelle | 0 | Cameron (9) | 44 | Hx 484 | |
| 2021-10-29 | A | W | Clay-Battelle | 28 | Calhoun County (2) | 14 | Hx 478 | |
| 2021-11-05 | A | W | Clay-Battelle | 58 | Hundred (0) | 0 | Hx 489 | |
| 2021-11-13 | A | L | Clay-Battelle | 14 | Ritchie County (13) | 46 | 4-13 1st RD | Hx 1266 |