| Date | H/A | W/L | Team | Score | Opponent | Score | ||
| 2021-08-27 | A | L | Valley-Wetzel | 0 | Tygarts Valley (4) | 49 | Hx 628 | |
| 2021-09-03 | A | L | Valley-Wetzel | 6 | Calhoun County (2) | 28 | Hx 471 | |
| 2021-09-10 | A | L | Valley-Wetzel | 8 | Clay-Battelle (8) | 49 | Hx 487 | |
| 2021-09-17 | H | L | Valley-Wetzel | 12 | Frontier (OH) (5) | 54 | Hx 448 | |
| 2021-09-24 | A | W | Valley-Wetzel | 38 | Beallsville (OH) (2) | 16 | Hx 449 | |
| 2021-10-01 | H | L | Valley-Wetzel | 6 | South Harrison (4) | 26 | Hx 619 | |
| 2021-10-08 | H | L | Valley-Wetzel | 8 | Cameron (9) | 62 | Hx 483 | |
| 2021-10-29 | H | L | Valley-Wetzel | 12 | Tyler Consolidated (6) | 55 | Hx 629 | |
| 2021-11-02 | H | W | Valley-Wetzel | 52 | Hundred (0) | 22 | Hx 1237 | |
| 2021-11-05 | A | W | Valley-Wetzel | 46 | Paden City (2) | 20 | Hx 590 |