| Date | H/A | W/L | Team | Score | Opponent | Score | ||
| 2021-08-28 | H | L | Calhoun County | 8 | Wirt County (4) | 54 | Hx 470 | |
| 2021-09-03 | H | W | Calhoun County | 28 | Valley-Wetzel (3) | 6 | Hx 471 | |
| 2021-09-20 | A | L | Calhoun County | 14 | Tyler Consolidated (6) | 46 | Hx 473 | |
| 2021-09-24 | H | L | Calhoun County | 0 | St. Marys (6) | 48 | Hx 474 | |
| 2021-10-01 | A | W | Calhoun County | 44 | Paden City (2) | 13 | Hx 475 | |
| 2021-10-18 | H | L | Calhoun County | 0 | Gilmer County (7) | 46 | Hx 476 | |
| 2021-10-23 | A | L | Calhoun County | 14 | Wahama (5) | 48 | Hx 477 | |
| 2021-10-27 | A | L | Calhoun County | 0 | Doddridge County (11) | 1 | Hx 1254 | |
| 2021-10-29 | H | L | Calhoun County | 14 | Clay-Battelle (8) | 28 | Hx 478 | |
| 2021-11-05 | H | L | Calhoun County | 20 | Ritchie County (13) | 45 | Hx 479 |