| Date | H/A | W/L | Team | Score | Opponent | Score | ||
| 2021-08-27 | H | W | Tygarts Valley | 49 | Valley-Wetzel (3) | 0 | Hx 628 | |
| 2021-09-03 | A | L | Tygarts Valley | 14 | Tucker County (2) | 16 | Hx 625 | |
| 2021-09-10 | A | W | Tygarts Valley | 43 | Webster County (2) | 14 | Hx 627 | |
| 2021-09-17 | A | L | Tygarts Valley | 14 | East Hardy (10) | 30 | Hx 500 | |
| 2021-09-24 | H | L | Tygarts Valley | 30 | Clay-Battelle (8) | 36 | Hx 488 | |
| 2021-10-01 | H | W | Tygarts Valley | 41 | Richwood (3) | 16 | Hx 607 | |
| 2021-10-08 | A | L | Tygarts Valley | 14 | Pendleton County (2) | 21 | Hx 593 | |
| 2021-10-22 | A | L | Tygarts Valley | 14 | Trinity (7) | 21 | Hx 570 | |
| 2021-10-29 | H | W | Tygarts Valley | 20 | Pocahontas County (5) | 0 | Hx 600 | |
| 2021-11-05 | H | L | Tygarts Valley | 0 | Doddridge County (11) | 34 | Hx 497 |