| Date | H/A | W/L | Team | Score | Opponent | Score | ||
| 2021-08-28 | A | W | Wirt County | 54 | Calhoun County (2) | 8 | Hx 470 | |
| 2021-09-03 | H | W | Wirt County | 27 | Magnolia (1) | 14 | Hx 542 | |
| 2021-09-10 | H | L | Wirt County | 12 | Gilmer County (7) | 39 | Hx 507 | |
| 2021-09-17 | A | W | Wirt County | 24 | Ravenswood (0) | 14 | Hx 563 | |
| 2021-09-24 | H | L | Wirt County | 0 | Tyler Consolidated (6) | 38 | Hx 564 | |
| 2021-10-01 | A | L | Wirt County | 0 | Doddridge County (11) | 34 | Hx 493 | |
| 2021-10-08 | H | L | Wirt County | 6 | St. Marys (6) | 22 | Hx 565 | |
| 2021-10-15 | H | W | Wirt County | 34 | Wahama (5) | 30 | Hx 566 | |
| 2021-10-22 | A | L | Wirt County | 7 | Ritchie County (13) | 40 | Hx 567 | |
| 2021-11-05 | A | L | Wirt County | 34 | Sherman (6) | 48 | Hx 568 |