| Date | H/A | W/L | Team | Score | Opponent | Score | ||
| 2021-08-27 | H | L | St. Marys | 0 | Roane County (6) | 6 | Hx 377 | |
| 2021-09-03 | A | W | St. Marys | 30 | Ravenswood (0) | 14 | Hx 601 | |
| 2021-09-17 | A | L | St. Marys | 7 | Ritchie County (13) | 36 | Hx 612 | |
| 2021-09-24 | A | W | St. Marys | 48 | Calhoun County (2) | 0 | Hx 474 | |
| 2021-10-01 | H | L | St. Marys | 13 | Williamstown (11) | 17 | Hx 561 | |
| 2021-10-08 | A | W | St. Marys | 22 | Wirt County (4) | 6 | Hx 565 | |
| 2021-10-15 | H | W | St. Marys | 34 | Magnolia (1) | 7 | Hx 543 | |
| 2021-10-22 | H | W | St. Marys | 41 | South Harrison (4) | 6 | Hx 620 | |
| 2021-10-29 | A | L | St. Marys | 6 | East Hardy (10) | 36 | Hx 504 | |
| 2021-11-05 | H | W | St. Marys | 36 | Tyler Consolidated (6) | 16 | Hx 622 |