| Date | H/A | W/L | Team | Score | Opponent | Score | ||
| 2021-08-27 | H | W | Magnolia | 43 | Ravenswood (0) | 27 | Hx 541 | |
| 2021-09-03 | A | L | Magnolia | 14 | Wirt County (4) | 27 | Hx 542 | |
| 2021-09-24 | H | L | Magnolia | 19 | Monroe Central (OH) (4) | 43 | Hx 420 | |
| 2021-10-01 | H | L | Magnolia | 23 | Union Local (OH) (5) | 26 | Hx 421 | |
| 2021-10-08 | A | L | Magnolia | 21 | Frontier (OH) (5) | 28 | Hx 422 | |
| 2021-10-15 | A | L | Magnolia | 7 | St. Marys (6) | 34 | Hx 543 | |
| 2021-10-22 | A | L | Magnolia | 7 | Tyler Consolidated (6) | 49 | Hx 544 | |
| 2021-10-29 | H | L | Magnolia | 18 | Wahama (5) | 42 | Hx 1159 | |
| 2021-11-05 | A | L | Magnolia | 6 | Williamstown (11) | 53 | Hx 545 |