| Date | H/A | W/L | Team | Score | Opponent | Score | ||
| 2021-08-30 | A | W | Liberty-Harrison | 33 | Elkins (0) | 6 | Hx 244 | |
| 2021-09-03 | H | L | Liberty-Harrison | 7 | South Harrison (4) | 30 | Hx 300 | |
| 2021-09-10 | H | L | Liberty-Harrison | 6 | Bridgeport (8) | 54 | Hx 22 | |
| 2021-09-17 | H | W | Liberty-Harrison | 34 | Philip Barbour (1) | 26 | Hx 301 | |
| 2021-09-24 | A | L | Liberty-Harrison | 34 | Grafton (5) | 41 | Hx 267 | |
| 2021-10-01 | A | W | Liberty-Harrison | 29 | Braxton County (1) | 26 | Hx 214 | |
| 2021-10-15 | H | W | Liberty-Harrison | 41 | East Fairmont (5) | 14 | Hx 241 | |
| 2021-10-22 | A | L | Liberty-Harrison | 14 | Lincoln (8) | 34 | Hx 302 | |
| 2021-10-29 | A | L | Liberty-Harrison | 0 | Robert C. Byrd (7) | 41 | Hx 303 | |
| 2021-11-05 | A | L | Liberty-Harrison | 0 | North Marion (8) | 55 | Hx 304 |