| Date | H/A | W/L | Team | Score | Opponent | Score | ||
| 2021-08-27 | A | W | Grafton | 40 | Pendleton County (2) | 14 | Hx 264 | |
| 2021-09-03 | A | L | Grafton | 35 | East Fairmont (5) | 37 | Hx 239 | |
| 2021-09-10 | H | L | Grafton | 7 | Lincoln (8) | 27 | Hx 265 | |
| 2021-09-17 | A | W | Grafton | 28 | South Harrison (4) | 20 | Hx 266 | |
| 2021-09-24 | H | W | Grafton | 41 | Liberty-Harrison (4) | 34 | Hx 267 | |
| 2021-10-01 | A | W | Grafton | 46 | Elkins (0) | 13 | Hx 248 | |
| 2021-10-08 | H | W | Grafton | 48 | Richwood (3) | 6 | Hx 268 | |
| 2021-10-22 | H | W | Grafton | 47 | Buckhannon-Upshur (0) | 14 | Hx 45 | |
| 2021-10-28 | H | W | Grafton | 1 | Philip Barbour (1) | 0 | Hx 1258 | |
| 2021-11-05 | H | W | Grafton | 48 | Lewis County (2) | 6 | Hx 270 | |
| 2021-11-12 | A | L | Grafton | 14 | North Marion (8) | 64 | 6-11 1st RD | Hx 1279 |