| Date | H/A | W/L | Team | Score | Opponent | Score | ||
| 2021-08-27 | A | L | South Harrison | 0 | Doddridge County (11) | 20 | Hx 490 | |
| 2021-09-03 | A | W | South Harrison | 30 | Liberty-Harrison (4) | 7 | Hx 300 | |
| 2021-09-10 | H | L | South Harrison | 0 | Tyler Consolidated (6) | 40 | Hx 618 | |
| 2021-09-17 | H | L | South Harrison | 20 | Grafton (5) | 28 | Hx 266 | |
| 2021-09-24 | H | L | South Harrison | 20 | Gilmer County (7) | 39 | Hx 509 | |
| 2021-10-01 | A | W | South Harrison | 26 | Valley-Wetzel (3) | 6 | Hx 619 | |
| 2021-10-08 | H | L | South Harrison | 20 | Ritchie County (13) | 50 | Hx 613 | |
| 2021-10-22 | A | L | South Harrison | 6 | St. Marys (6) | 41 | Hx 620 | |
| 2021-10-29 | H | W | South Harrison | 44 | Braxton County (1) | 14 | Hx 218 | |
| 2021-11-05 | A | W | South Harrison | 36 | Tucker County (2) | 24 | Hx 621 |