| Date | H/A | W/L | Team | Score | Opponent | Score | ||
| 2021-08-27 | H | W | Wayne | 38 | Tolsia (0) | 14 | Hx 393 | |
| 2021-09-03 | A | L | Wayne | 14 | Scott (6) | 35 | Hx 382 | |
| 2021-09-10 | H | L | Wayne | 20 | Logan (5) | 27 | Hx 319 | |
| 2021-09-17 | A | L | Wayne | 20 | Winfield (5) | 35 | Hx 392 | |
| 2021-09-24 | H | W | Wayne | 28 | Nitro (2) | 14 | Hx 337 | |
| 2021-10-01 | A | L | Wayne | 22 | Liberty-Raleigh (6) | 30 | Hx 307 | |
| 2021-10-08 | H | L | Wayne | 0 | Herbert Hoover (10) | 53 | Hx 276 | |
| 2021-10-15 | A | L | Wayne | 16 | Chapmanville Regional (3) | 40 | Hx 226 | |
| 2021-10-22 | A | L | Wayne | 22 | Sissonville (2) | 45 | Hx 391 | |
| 2021-11-05 | H | W | Wayne | 26 | Poca (9) | 20 | Hx 359 |