| Date | H/A | W/L | Team | Score | Opponent | Score | ||
| 2021-08-27 | A | W | Herbert Hoover | 24 | Scott (6) | 9 | Hx 271 | |
| 2021-09-03 | A | W | Herbert Hoover | 37 | Winfield (5) | 14 | Hx 272 | |
| 2021-09-10 | H | W | Herbert Hoover | 48 | Nitro (2) | 0 | Hx 273 | |
| 2021-09-17 | H | W | Herbert Hoover | 70 | Wyoming East (1) | 6 | Hx 274 | |
| 2021-09-24 | A | W | Herbert Hoover | 70 | Sissonville (2) | 0 | Hx 275 | |
| 2021-10-01 | H | W | Herbert Hoover | 55 | Chapmanville Regional (3) | 7 | Hx 225 | |
| 2021-10-08 | A | W | Herbert Hoover | 53 | Wayne (2) | 0 | Hx 276 | |
| 2021-10-22 | A | W | Herbert Hoover | 57 | Mingo Central (2) | 0 | Hx 277 | |
| 2021-10-29 | H | W | Herbert Hoover | 28 | Poca (9) | 0 | Hx 278 | |
| 2021-11-05 | H | W | Herbert Hoover | 48 | Logan (5) | 6 | Hx 279 | |
| 2021-11-13 | H | L | Herbert Hoover | 28 | Fairmont Sr. (9) | 30 | 1-16 1st RD | Hx 1272 |