| Date | H/A | W/L | Team | Score | Opponent | Score | ||
| 2021-08-27 | H | L | Nitro | 7 | Poca (9) | 28 | Hx 336 | |
| 2021-09-03 | A | L | Nitro | 3 | St. Albans (2) | 6 | Hx 189 | |
| 2021-09-10 | A | L | Nitro | 0 | Herbert Hoover (10) | 48 | Hx 273 | |
| 2021-09-17 | H | L | Nitro | 18 | Chapmanville Regional (3) | 29 | Hx 223 | |
| 2021-09-24 | A | L | Nitro | 14 | Wayne (2) | 28 | Hx 337 | |
| 2021-10-01 | H | L | Nitro | 0 | Logan (5) | 19 | Hx 321 | |
| 2021-10-08 | A | W | Nitro | 1 | Clay County (3) | 0 | Hx 236 | |
| 2021-10-22 | A | L | Nitro | 0 | Winfield (5) | 34 | Hx 338 | |
| 2021-10-29 | H | W | Nitro | 32 | Sissonville (2) | 7 | Hx 339 | |
| 2021-11-05 | H | L | Nitro | 18 | Scott (6) | 22 | Hx 340 |