| Date | H/A | W/L | Team | Score | Opponent | Score | ||
| 2021-08-27 | H | W | Sissonville | 24 | Chapmanville Regional (3) | 20 | Hx 220 | |
| 2021-09-03 | A | L | Sissonville | 14 | Logan (5) | 40 | Hx 318 | |
| 2021-09-10 | H | L | Sissonville | 21 | Scott (6) | 48 | Hx 383 | |
| 2021-09-17 | H | L | Sissonville | 7 | Clay County (3) | 18 | Hx 233 | |
| 2021-09-24 | H | L | Sissonville | 0 | Herbert Hoover (10) | 70 | Hx 275 | |
| 2021-10-01 | A | L | Sissonville | 6 | Poca (9) | 34 | Hx 356 | |
| 2021-10-15 | A | L | Sissonville | 7 | Winfield (5) | 44 | Hx 390 | |
| 2021-10-22 | H | W | Sissonville | 45 | Wayne (2) | 22 | Hx 391 | |
| 2021-10-29 | A | L | Sissonville | 7 | Nitro (2) | 32 | Hx 339 | |
| 2021-11-05 | A | L | Sissonville | 40 | Roane County (6) | 58 | Hx 381 |