| Date | H/A | W/L | Team | Score | Opponent | Score | ||
| 2021-08-20 | A | L | Painesville Riverside (OH) | 6 | Perry (OH) (3) | 26 | Hx 896 | |
| 2021-08-27 | H | W | Painesville Riverside (OH) | 49 | Amherst Steele (OH) (0) | 14 | Hx 897 | |
| 2021-09-03 | H | W | Painesville Riverside (OH) | 28 | Parma Heights Holy Name (OH) (0) | 7 | Hx 898 | |
| 2021-09-10 | A | L | Painesville Riverside (OH) | 7 | Chardon (OH) (4) | 28 | Hx 899 | |
| 2021-09-17 | A | W | Painesville Riverside (OH) | 45 | Madison (OH) (0) | 0 | Hx 900 | |
| 2021-09-24 | H | W | Painesville Riverside (OH) | 57 | Cleveland Mayfield (OH) (2) | 7 | Hx 901 | |
| 2021-10-01 | A | W | Painesville Riverside (OH) | 42 | East Lake North (OH) (1) | 14 | Hx 1124 | |
| 2021-10-09 | H | L | Painesville Riverside (OH) | 33 | Martinsburg (13) | 45 | Hx 258 | |
| 2021-10-15 | A | L | Painesville Riverside (OH) | 14 | Chagrin Falls Kensten (OH) (4) | 21 | Hx 902 | |
| 2021-10-22 | H | W | Painesville Riverside (OH) | 14 | Willoughby South (OH) (4) | 7 | Hx 903 |