| Date | H/A | W/L | Team | Score | Opponent | Score | ||
| 2021-09-17 | H | L | Cleveland Mayfield (OH) | 7 | Chardon (OH) (4) | 41 | Hx 1250 | |
| 2021-09-24 | A | L | Cleveland Mayfield (OH) | 7 | Painesville Riverside (OH) (5) | 57 | Hx 901 | |
| 2021-10-01 | A | L | Cleveland Mayfield (OH) | 15 | Willoughby South (OH) (4) | 21 | Hx 1249 | |
| 2021-10-08 | H | W | Cleveland Mayfield (OH) | 16 | East Lake North (OH) (1) | 7 | Hx 1248 | |
| 2021-10-15 | A | W | Cleveland Mayfield (OH) | 21 | Madison (OH) (0) | 6 | Hx 1247 | |
| 2021-10-22 | H | L | Cleveland Mayfield (OH) | 15 | Chagrin Falls Kensten (OH) (4) | 17 | Hx 1246 |