| Date | H/A | W/L | Team | Score | Opponent | Score | ||
| 2021-08-27 | A | W | Linsly (WV) | 27 | Martins Ferry (OH) (1) | 14 | Hx 364 | |
| 2021-09-04 | H | W | Linsly (WV) | 31 | Fairmont Sr. (9) | 22 | Hx 254 | |
| 2021-09-11 | A | W | Linsly (WV) | 35 | Cardinal Mooney (OH) (0) | 21 | Hx 365 | |
| 2021-09-17 | A | L | Linsly (WV) | 14 | St. Clairsville (OH) (4) | 35 | Hx 1160 | |
| 2021-09-24 | A | L | Linsly (WV) | 17 | Steubenville (OH) (7) | 26 | Hx 366 | |
| 2021-10-01 | H | W | Linsly (WV) | 26 | McGuffey (PA) (0) | 21 | Hx 367 | |
| 2021-10-08 | A | W | Linsly (WV) | 41 | Canton Central Cath. (OH) (0) | 20 | Hx 368 | |
| 2021-10-15 | A | L | Linsly (WV) | 0 | Dover (OH) (4) | 42 | Hx 369 | |
| 2021-10-23 | H | L | Linsly (WV) | 14 | Louisville (OH) (1) | 20 | Hx 370 | |
| 2021-10-29 | A | L | Linsly (WV) | 14 | Hollidaysburg (PA) (0) | 19 | Hx 371 |