| Date | H/A | W/L | Team | Score | Opponent | Score | ||
| 2021-08-20 | A | L | Martins Ferry (OH) | 6 | Shadyside (OH) (8) | 26 | Hx 743 | |
| 2021-08-27 | H | L | Martins Ferry (OH) | 14 | Linsly (WV) (4) | 27 | Hx 364 | |
| 2021-09-04 | A | L | Martins Ferry (OH) | 28 | Union Local (OH) (5) | 30 | Hx 744 | |
| 2021-09-10 | H | L | Martins Ferry (OH) | 6 | St. Clairsville (OH) (4) | 56 | Hx 745 | |
| 2021-09-17 | H | W | Martins Ferry (OH) | 38 | Weir (2) | 7 | Hx 373 | |
| 2021-09-24 | H | L | Martins Ferry (OH) | 0 | Cambridge (OH) (3) | 23 | Hx 746 | |
| 2021-10-01 | A | L | Martins Ferry (OH) | 14 | Indian Creek (OH) (0) | 26 | Hx 726 | |
| 2021-10-08 | H | L | Martins Ferry (OH) | 6 | Wheeling Central (9) | 47 | Hx 455 | |
| 2021-10-15 | A | L | Martins Ferry (OH) | 18 | Beaver Local (OH) (3) | 44 | Hx 687 | |
| 2021-10-23 | A | L | Martins Ferry (OH) | 6 | Bellaire (OH) (9) | 35 | Hx 677 |