| Date | H/A | W/L | Team | Score | Opponent | Score | ||
| 2021-08-20 | A | W | St. Clairsville (OH) | 42 | Carrollton (OH) (0) | 35 | Hx 797 | |
| 2021-08-27 | H | L | St. Clairsville (OH) | 14 | Wheeling Park (3) | 18 | Hx 153 | |
| 2021-09-03 | H | W | St. Clairsville (OH) | 38 | South Allegheny (PA) (0) | 7 | Hx 796 | |
| 2021-09-10 | A | W | St. Clairsville (OH) | 56 | Martins Ferry (OH) (1) | 6 | Hx 745 | |
| 2021-09-17 | H | W | St. Clairsville (OH) | 35 | Linsly (WV) (4) | 14 | Hx 1160 | |
| 2021-09-24 | H | W | St. Clairsville (OH) | 55 | Harrison Central (OH) (1) | 7 | Hx 798 | |
| 2021-10-02 | A | W | St. Clairsville (OH) | 28 | Bellaire (OH) (9) | 16 | Hx 674 | |
| 2021-10-08 | H | W | St. Clairsville (OH) | 55 | Union Local (OH) (5) | 7 | Hx 799 | |
| 2021-10-14 | H | W | St. Clairsville (OH) | 35 | Wheeling Central (9) | 0 | Hx 456 | |
| 2021-10-22 | H | W | St. Clairsville (OH) | 55 | Cambridge (OH) (3) | 28 | Hx 800 |