| Date | H/A | W/L | Team | Score | Opponent | Score | ||
| 2021-08-20 | H | W | Conotton Valley (OH) | 48 | Strasburg-Franklin (OH) (0) | 8 | Hx 693 | |
| 2021-08-27 | A | L | Conotton Valley (OH) | 12 | Malvern (OH) (2) | 40 | Hx 694 | |
| 2021-09-10 | H | W | Conotton Valley (OH) | 24 | St. Thomas Aquinas (OH) (0) | 20 | Hx 1158 | |
| 2021-09-17 | A | L | Conotton Valley (OH) | 16 | East Knox (OH) (1) | 42 | Hx 1164 | |
| 2021-09-24 | A | L | Conotton Valley (OH) | 16 | Caldwell (OH) (4) | 21 | Hx 697 | |
| 2021-10-01 | H | W | Conotton Valley (OH) | 20 | Steubenville Central (OH) (3) | 14 | Hx 698 | |
| 2021-10-08 | H | W | Conotton Valley (OH) | 54 | Beallsville (OH) (2) | 14 | Hx 680 | |
| 2021-10-15 | H | L | Conotton Valley (OH) | 6 | River (OH) (6) | 35 | Hx 699 | |
| 2021-10-23 | A | W | Conotton Valley (OH) | 40 | Madonna (6) | 28 | Hx 418 |