| Date | H/A | W/L | Team | Score | Opponent | Score | ||
| 2021-08-19 | H | L | River (OH) | 14 | Bellaire (OH) (9) | 34 | Hx 663 | |
| 2021-08-27 | H | W | River (OH) | 35 | Marietta (OH) (1) | 14 | Hx 748 | |
| 2021-09-03 | H | W | River (OH) | 48 | Monroe Central (OH) (4) | 26 | Hx 768 | |
| 2021-09-10 | A | L | River (OH) | 24 | Warren Local (OH) (1) | 54 | Hx 1157 | |
| 2021-09-17 | A | L | River (OH) | 21 | Barnesville (OH) (5) | 40 | Hx 790 | |
| 2021-09-24 | A | L | River (OH) | 12 | Shadyside (OH) (8) | 14 | Hx 791 | |
| 2021-10-01 | H | W | River (OH) | 58 | Belpre (OH) (1) | 12 | Hx 792 | |
| 2021-10-08 | H | W | River (OH) | 50 | Bridgeport (OH) (3) | 14 | Hx 691 | |
| 2021-10-15 | A | W | River (OH) | 35 | Conotton Valley (OH) (5) | 6 | Hx 699 | |
| 2021-10-22 | A | W | River (OH) | 56 | Frontier (OH) (5) | 13 | Hx 713 |