| Date | H/A | W/L | Team | Score | Opponent | Score | ||
| 2021-09-03 | H | W | Graham (VA) | 34 | Tazewell (VA) (3) | 6 | Hx 1020 | |
| 2021-09-10 | A | W | Graham (VA) | 35 | Richlands (VA) (3) | 0 | Hx 1021 | |
| 2021-09-16 | H | W | Graham (VA) | 28 | Union (VA) (2) | 27 | Hx 1022 | |
| 2021-09-24 | A | W | Graham (VA) | 28 | Galax (VA) (0) | 0 | Hx 1023 | |
| 2021-10-08 | A | W | Graham (VA) | 31 | Bluefield (7) | 6 | Hx 204 | |
| 2021-10-15 | H | W | Graham (VA) | 56 | Virginia (VA) (1) | 23 | Hx 1025 | |
| 2021-10-22 | A | W | Graham (VA) | 58 | Pulaski County (VA) (4) | 18 | Hx 1026 | |
| 2021-10-28 | H | W | Graham (VA) | 46 | Blacksburg (VA) (0) | 7 | Hx 1027 | |
| 2021-11-04 | H | W | Graham (VA) | 49 | Marion (VA) (0) | 14 | Hx 1028 |