| Date | H/A | W/L | Team | Score | Opponent | Score | ||
| 2021-08-27 | A | W | Wheeling Park | 18 | St. Clairsville (OH) (4) | 14 | Hx 153 | |
| 2021-09-03 | A | L | Wheeling Park | 16 | Steubenville (OH) (7) | 45 | Hx 154 | |
| 2021-09-18 | H | L | Wheeling Park | 14 | University (10) | 35 | Hx 190 | |
| 2021-10-08 | A | W | Wheeling Park | 41 | Morgantown (5) | 6 | Hx 142 | |
| 2021-10-15 | A | L | Wheeling Park | 17 | Musselman (3) | 25 | Hx 158 | |
| 2021-10-22 | H | W | Wheeling Park | 56 | Brooke (3) | 7 | Hx 36 | |
| 2021-10-29 | H | L | Wheeling Park | 24 | Parkersburg South (5) | 26 | Hx 18 | |
| 2021-11-05 | A | W | Wheeling Park | 35 | John Marshall (3) | 7 | Hx 123 | |
| 2021-11-12 | A | L | Wheeling Park | 21 | Huntington (13) | 48 | 1-16 1st RD | Hx 1280 |