| Date | H/A | W/L | Team | Score | Opponent | Score | ||
| 2021-08-27 | H | W | Clay-Battelle | 48 | Federal Hocking (OH) () | 0 | 774 | |
| 2021-09-03 | H | L | Clay-Battelle | 12 | East Hardy () | 45 | 486 | |
| 2021-09-10 | H | W | Clay-Battelle | 49 | Valley-Wetzel () | 8 | 487 | |
| 2021-09-17 | H | W | Clay-Battelle | 50 | Beallsville (OH) () | 18 | 404 | |
| 2021-09-24 | A | W | Clay-Battelle | 36 | Tygarts Valley () | 30 | 488 | |
| 2021-10-01 | H | W | Clay-Battelle | 41 | Hancock (MD) () | 0 | 405 | |
| 2021-10-08 | A | W | Clay-Battelle | 56 | Massanutten Mil. Acad. (VA) () | 0 | 406 | |
| 2021-10-15 | A | L | Clay-Battelle | 0 | Cameron () | 44 | 484 | |
| 2021-10-29 | A | W | Clay-Battelle | 28 | Calhoun County () | 14 | 478 | |
| 2021-11-05 | A | W | Clay-Battelle | 58 | Hundred () | 0 | 489 | |
| 2021-11-13 | A | L | Clay-Battelle | 14 | Ritchie County () | 46 | 4-13 1st RD | 1266 |