| Date | H/A | W/L | Team | Score | Opponent | Score | ||
| 2021-08-28 | A | W | Wirt County | 54 | Calhoun County () | 8 | 470 | |
| 2021-09-03 | H | W | Wirt County | 27 | Magnolia () | 14 | 542 | |
| 2021-09-10 | H | L | Wirt County | 12 | Gilmer County () | 39 | 507 | |
| 2021-09-17 | A | W | Wirt County | 24 | Ravenswood () | 14 | 563 | |
| 2021-09-24 | H | L | Wirt County | 0 | Tyler Consolidated () | 38 | 564 | |
| 2021-10-01 | A | L | Wirt County | 0 | Doddridge County () | 34 | 493 | |
| 2021-10-08 | H | L | Wirt County | 6 | St. Marys () | 22 | 565 | |
| 2021-10-15 | H | W | Wirt County | 34 | Wahama () | 30 | 566 | |
| 2021-10-22 | A | L | Wirt County | 7 | Ritchie County () | 40 | 567 | |
| 2021-11-05 | A | L | Wirt County | 34 | Sherman () | 48 | 568 |