| Date | H/A | W/L | Team | Score | Opponent | Score | ||
| 2021-08-30 | A | W | Liberty-Harrison | 33 | Elkins () | 6 | 244 | |
| 2021-09-03 | H | L | Liberty-Harrison | 7 | South Harrison () | 30 | 300 | |
| 2021-09-10 | H | L | Liberty-Harrison | 6 | Bridgeport () | 54 | 22 | |
| 2021-09-17 | H | W | Liberty-Harrison | 34 | Philip Barbour () | 26 | 301 | |
| 2021-09-24 | A | L | Liberty-Harrison | 34 | Grafton () | 41 | 267 | |
| 2021-10-01 | A | W | Liberty-Harrison | 29 | Braxton County () | 26 | 214 | |
| 2021-10-15 | H | W | Liberty-Harrison | 41 | East Fairmont () | 14 | 241 | |
| 2021-10-22 | A | L | Liberty-Harrison | 14 | Lincoln () | 34 | 302 | |
| 2021-10-29 | A | L | Liberty-Harrison | 0 | Robert C. Byrd () | 41 | 303 | |
| 2021-11-05 | A | L | Liberty-Harrison | 0 | North Marion () | 55 | 304 |