| Date | H/A | W/L | Team | Score | Opponent | Score | ||
| 2021-08-27 | H | W | Wayne | 38 | Tolsia () | 14 | 393 | |
| 2021-09-03 | A | L | Wayne | 14 | Scott () | 35 | 382 | |
| 2021-09-10 | H | L | Wayne | 20 | Logan () | 27 | 319 | |
| 2021-09-17 | A | L | Wayne | 20 | Winfield () | 35 | 392 | |
| 2021-09-24 | H | W | Wayne | 28 | Nitro () | 14 | 337 | |
| 2021-10-01 | A | L | Wayne | 22 | Liberty-Raleigh () | 30 | 307 | |
| 2021-10-08 | H | L | Wayne | 0 | Herbert Hoover () | 53 | 276 | |
| 2021-10-15 | A | L | Wayne | 16 | Chapmanville Regional () | 40 | 226 | |
| 2021-10-22 | A | L | Wayne | 22 | Sissonville () | 45 | 391 | |
| 2021-11-05 | H | W | Wayne | 26 | Poca () | 20 | 359 |