| Date | H/A | W/L | Team | Score | Opponent | Score | ||
| 2021-08-27 | H | L | Nitro | 7 | Poca () | 28 | 336 | |
| 2021-09-03 | A | L | Nitro | 3 | St. Albans () | 6 | 189 | |
| 2021-09-10 | A | L | Nitro | 0 | Herbert Hoover () | 48 | 273 | |
| 2021-09-17 | H | L | Nitro | 18 | Chapmanville Regional () | 29 | 223 | |
| 2021-09-24 | A | L | Nitro | 14 | Wayne () | 28 | 337 | |
| 2021-10-01 | H | L | Nitro | 0 | Logan () | 19 | 321 | |
| 2021-10-08 | A | W | Nitro | 1 | Clay County () | 0 | 236 | |
| 2021-10-22 | A | L | Nitro | 0 | Winfield () | 34 | 338 | |
| 2021-10-29 | H | W | Nitro | 32 | Sissonville () | 7 | 339 | |
| 2021-11-05 | H | L | Nitro | 18 | Scott () | 22 | 340 |