| Date | H/A | W/L | Team | Score | Opponent | Score | ||
| 2021-08-27 | H | L | Williamstown | 12 | Waterford (OH) (6) | 18 | 2 OT Hx 458 | |
| 2021-09-04 | A | W | Williamstown | 34 | Warren Local (OH) (1) | 6 | Hx 459 | |
| 2021-09-10 | H | W | Williamstown | 35 | Ravenswood (0) | 8 | Hx 560 | |
| 2021-09-17 | A | W | Williamstown | 49 | Buffalo (5) | 6 | Hx 463 | |
| 2021-10-01 | A | W | Williamstown | 17 | St. Marys (6) | 13 | Hx 561 | |
| 2021-10-08 | A | W | Williamstown | 31 | Weir (2) | 6 | Hx 395 | |
| 2021-10-15 | A | W | Williamstown | 42 | Tyler Consolidated (6) | 22 | Hx 562 | |
| 2021-10-22 | H | L | Williamstown | 9 | Fort Frye (OH) (7) | 41 | Hx 460 | |
| 2021-10-29 | H | W | Williamstown | 26 | Doddridge County (11) | 24 | Hx 496 | |
| 2021-11-05 | H | W | Williamstown | 53 | Magnolia (1) | 6 | Hx 545 | |
| 2021-11-13 | H | W | Williamstown | 48 | Greenbrier West (6) | 20 | 6-11 1st RD | Hx 1271 |
| 2021-11-19 | A | W | Williamstown | 44 | East Hardy (10) | 24 | Quarterfinals | Hx 1302 |
| 2021-11-26 | A | W | Williamstown | 43 | Doddridge County (11) | 0 | Semifinals | Hx 1311 |
| 2021-12-04 | N | L | Williamstown | 21 | Ritchie County (13) | 42 | A CHAMPIONSHIP | Hx 1320 |