| Date | H/A | W/L | Team | Score | Opponent | Score | ||
| 2021-08-27 | H | W | Buffalo | 21 | Greenbrier West (6) | 20 | 1 OT Hx 461 | |
| 2021-09-17 | H | L | Buffalo | 6 | Williamstown (11) | 49 | Hx 463 | |
| 2021-09-25 | H | L | Buffalo | 3 | Roane County (6) | 22 | Hx 378 | |
| 2021-10-01 | A | L | Buffalo | 6 | Man (4) | 20 | Hx 464 | |
| 2021-10-08 | A | L | Buffalo | 0 | Tyler Consolidated (6) | 35 | Hx 465 | |
| 2021-10-15 | A | W | Buffalo | 47 | Tolsia (0) | 6 | Hx 466 | |
| 2021-10-22 | H | W | Buffalo | 26 | Ravenswood (0) | 21 | Hx 467 | |
| 2021-10-29 | A | W | Buffalo | 27 | Van (5) | 0 | Hx 468 | |
| 2021-11-05 | H | W | Buffalo | 20 | Wahama (5) | 14 | Hx 469 |