| Date | H/A | W/L | Team | Score | Opponent | Score | ||
| 0000-00-00 | H | Independence | Fairmont Sr. (9) | AA CHAMPIONSHIP | Hx 1317 | |||
| 0000-00-00 | H | Independence | Fairmont Sr. (9) | AA CHAMPIONSHIP | Hx 1316 | |||
| 2021-08-27 | A | W | Independence | 47 | Liberty-Raleigh (6) | 0 | Hx 280 | |
| 2021-09-17 | H | W | Independence | 50 | Shady Spring (5) | 17 | Hx 282 | |
| 2021-09-28 | H | W | Independence | 63 | Westside (1) | 14 | Hx 283 | |
| 2021-10-01 | A | W | Independence | 56 | Summers County (2) | 7 | Hx 284 | |
| 2021-10-08 | A | W | Independence | 60 | Midland Trail (6) | 21 | Hx 285 | |
| 2021-10-15 | H | W | Independence | 74 | Man (4) | 7 | Hx 286 | |
| 2021-10-22 | A | W | Independence | 57 | Nicholas County (6) | 21 | Hx 287 | |
| 2021-10-29 | H | W | Independence | 60 | Wyoming East (1) | 8 | Hx 288 | |
| 2021-11-12 | H | W | Independence | 73 | Shady Spring (5) | 7 | 2-15 1st RD | Hx 1276 |
| 2021-11-19 | H | W | Independence | 22 | Roane County (6) | 8 | Quarterfinals | Hx 1300 |
| 2021-11-26 | H | W | Independence | 34 | Bluefield (7) | 20 | Semifinals | Hx 1310 |
| 2021-12-03 | N | L | Independence | 12 | Fairmont Sr. (9) | 21 | AA CHAMPIONSHIP | Hx 1318 |