| Date | H/A | W/L | Team | Score | Opponent | Score | ||
| 2021-08-27 | A | W | Nicholas County | 27 | Oak Hill (2) | 25 | Hx 160 | |
| 2021-09-03 | A | W | Nicholas County | 38 | Shady Spring (5) | 14 | Hx 330 | |
| 2021-09-16 | H | L | Nicholas County | 13 | Lincoln (8) | 21 | Hx 313 | |
| 2021-09-24 | H | W | Nicholas County | 53 | Wyoming East (1) | 8 | Hx 331 | |
| 2021-10-01 | A | W | Nicholas County | 47 | Midland Trail (6) | 22 | Hx 332 | |
| 2021-10-08 | A | W | Nicholas County | 57 | Braxton County (1) | 13 | Hx 215 | |
| 2021-10-15 | H | W | Nicholas County | 1 | Westside (1) | 0 | Hx 1233 | |
| 2021-10-22 | H | L | Nicholas County | 21 | Independence (8) | 57 | Hx 287 | |
| 2021-10-29 | H | W | Nicholas County | 25 | James Monroe (8) | 7 | Hx 334 | |
| 2021-11-05 | H | W | Nicholas County | 54 | PikeView (1) | 14 | Hx 335 | |
| 2021-11-12 | H | L | Nicholas County | 15 | Roane County (6) | 18 | 7-10 1st RD | Hx 1277 |