| Date | H/A | W/L | Team | Score | Opponent | Score | ||
| 2021-08-27 | H | L | Man | 14 | Logan (5) | 21 | Hx 317 | |
| 2021-09-10 | A | W | Man | 49 | Westside (1) | 14 | Hx 397 | |
| 2021-09-17 | H | W | Man | 7 | Mingo Central (2) | 6 | Hx 326 | |
| 2021-09-24 | A | L | Man | 21 | Wheeling Central (9) | 49 | Hx 547 | |
| 2021-10-01 | H | W | Man | 20 | Buffalo (5) | 6 | Hx 464 | |
| 2021-10-05 | H | L | Man | 21 | Mt. View (10) | 45 | Hx 546 | |
| 2021-10-15 | A | L | Man | 7 | Independence (8) | 74 | Hx 286 | |
| 2021-10-22 | A | L | Man | 14 | Pt. Pleasant (8) | 41 | Hx 362 | |
| 2021-10-29 | H | W | Man | 35 | Tug Valley (4) | 28 | Hx 548 | |
| 2021-11-05 | A | L | Man | 28 | Chapmanville Regional (3) | 40 | Hx 229 |