| Date | H/A | W/L | Team | Score | Opponent | Score | ||
| 2021-08-27 | A | W | Roane County | 6 | St. Marys (6) | 0 | Hx 377 | |
| 2021-09-03 | H | L | Roane County | 28 | Lincoln County (2) | 30 | Hx 125 | |
| 2021-09-10 | A | W | Roane County | 1 | Clay County (3) | 0 | Hx 1197 | |
| 2021-09-20 | H | W | Roane County | 55 | Lewis County (2) | 0 | Hx 296 | |
| 2021-09-25 | A | W | Roane County | 22 | Buffalo (5) | 3 | Hx 378 | |
| 2021-10-01 | A | W | Roane County | 44 | Ripley (1) | 7 | Hx 174 | |
| 2021-10-15 | H | W | Roane County | 57 | Braxton County (1) | 6 | Hx 216 | |
| 2021-10-22 | A | L | Roane County | 16 | Doddridge County (11) | 44 | Hx 379 | |
| 2021-10-29 | A | W | Roane County | 28 | Ravenswood (0) | 7 | Hx 380 | |
| 2021-11-05 | H | W | Roane County | 58 | Sissonville (2) | 40 | Hx 381 | |
| 2021-11-12 | A | W | Roane County | 18 | Nicholas County (6) | 15 | 7-10 1st RD | Hx 1277 |
| 2021-11-19 | A | L | Roane County | 8 | Independence (8) | 22 | Quarterfinals | Hx 1300 |