| Date | H/A | W/L | Team | Score | Opponent | Score | ||
| 2021-09-10 | H | L | Barnesville (OH) | 14 | Shadyside (OH) (8) | 35 | Hx 795 | |
| 2021-09-17 | H | W | Barnesville (OH) | 40 | River (OH) (6) | 21 | Hx 790 | |
| 2021-09-25 | A | W | Barnesville (OH) | 50 | Steubenville Central (OH) (3) | 0 | Hx 813 | |
| 2021-10-01 | A | W | Barnesville (OH) | 37 | Toronto (OH) (5) | 0 | Hx 827 | |
| 2021-10-08 | H | W | Barnesville (OH) | 57 | Monroe Central (OH) (4) | 12 | Hx 772 | |
| 2021-10-22 | A | W | Barnesville (OH) | 26 | Union Local (OH) (5) | 21 | Hx 848 |