| Date | H/A | W/L | Team | Score | Opponent | Score | ||
| 2021-08-20 | A | W | Union Local (OH) | 40 | Monroe Central (OH) (4) | 18 | Hx 767 | |
| 2021-09-04 | H | W | Union Local (OH) | 30 | Martins Ferry (OH) (1) | 28 | Hx 744 | |
| 2021-09-09 | A | W | Union Local (OH) | 41 | Harrison Central (OH) (1) | 18 | Hx 845 | |
| 2021-09-17 | A | W | Union Local (OH) | 49 | Shenandoah (OH) (1) | 20 | Hx 846 | |
| 2021-09-24 | H | L | Union Local (OH) | 12 | Westinghouse (PA) (2) | 56 | Hx 847 | |
| 2021-10-01 | A | W | Union Local (OH) | 26 | Magnolia (1) | 23 | Hx 421 | |
| 2021-10-08 | A | L | Union Local (OH) | 7 | St. Clairsville (OH) (4) | 55 | Hx 799 | |
| 2021-10-15 | H | L | Union Local (OH) | 0 | Bellaire (OH) (9) | 14 | Hx 676 | |
| 2021-10-22 | H | L | Union Local (OH) | 21 | Barnesville (OH) (5) | 26 | Hx 848 |