| Date | H/A | W/L | Team | Score | Opponent | Score | ||
| 2021-08-20 | H | L | Monroe Central (OH) | 18 | Union Local (OH) (5) | 40 | Hx 767 | |
| 2021-08-28 | A | W | Monroe Central (OH) | 42 | Bridgeport (OH) (3) | 22 | Hx 688 | |
| 2021-09-03 | A | L | Monroe Central (OH) | 26 | River (OH) (6) | 48 | Hx 768 | |
| 2021-09-10 | A | L | Monroe Central (OH) | 46 | Caldwell (OH) (4) | 73 | Hx 769 | |
| 2021-09-24 | A | W | Monroe Central (OH) | 43 | Magnolia (1) | 19 | Hx 420 | |
| 2021-10-01 | H | W | Monroe Central (OH) | 36 | Shenandoah (OH) (1) | 28 | Hx 771 | |
| 2021-10-08 | A | L | Monroe Central (OH) | 12 | Barnesville (OH) (5) | 57 | Hx 772 | |
| 2021-10-15 | H | W | Monroe Central (OH) | 46 | Frontier (OH) (5) | 28 | Hx 714 | |
| 2021-10-22 | H | L | Monroe Central (OH) | 20 | Shadyside (OH) (8) | 21 | Hx 773 |