| Date | H/A | W/L | Team | Score | Opponent | Score | ||
| 2021-09-03 | A | L | Bluefield | 36 | Princeton (4) | 39 | Hx 172 | |
| 2021-10-08 | H | L | Bluefield | 6 | Graham (VA) (9) | 31 | Hx 204 | |
| 2021-10-11 | H | W | Bluefield | 66 | PikeView (1) | 0 | Hx 207 | |
| 2021-10-15 | A | W | Bluefield | 57 | Tazewell (VA) (3) | 14 | Hx 208 | |
| 2021-10-22 | A | W | Bluefield | 41 | Oak Hill (2) | 21 | Hx 164 | |
| 2021-10-27 | A | L | Bluefield | 0 | Woodrow Wilson (4) | 1 | Hx 1256 | |
| 2021-10-29 | A | W | Bluefield | 21 | Ridgeview (VA) (5) | 19 | Hx 209 | |
| 2021-11-05 | H | W | Bluefield | 55 | Mingo Central (2) | 6 | Hx 210 | |
| 2021-11-13 | A | W | Bluefield | 44 | Pt. Pleasant (8) | 20 | 3-14 1st RD | Hx 1278 |
| 2021-11-19 | A | W | Bluefield | 35 | North Marion (8) | 21 | Quarterfinals | Hx 1301 |
| 2021-11-26 | A | L | Bluefield | 20 | Independence (8) | 34 | Semifinals | Hx 1310 |