| Date | H/A | W/L | Team | Score | Opponent | Score | ||
| 2021-09-03 | H | L | Harrison Central (OH) | 0 | Bellaire (OH) (9) | 27 | Hx 671 | |
| 2021-09-09 | H | L | Harrison Central (OH) | 18 | Union Local (OH) (5) | 41 | Hx 845 | |
| 2021-09-24 | A | L | Harrison Central (OH) | 7 | St. Clairsville (OH) (4) | 55 | Hx 798 | |
| 2021-10-01 | A | L | Harrison Central (OH) | 14 | Beaver Local (OH) (3) | 48 | Hx 685 | |
| 2021-10-15 | H | W | Harrison Central (OH) | 33 | Indian Creek (OH) (0) | 23 | Hx 727 |