| Date | H/A | W/L | Team | Score | Opponent | Score | ||
| 2021-08-20 | H | L | Beaver Local (OH) | 26 | Indian Valley (OH) (1) | 37 | Hx 665 | |
| 2021-08-27 | A | L | Beaver Local (OH) | 35 | Salem (OH) (2) | 62 | Hx 681 | |
| 2021-09-03 | A | W | Beaver Local (OH) | 56 | Minerva (OH) (0) | 7 | Hx 682 | |
| 2021-09-10 | H | W | Beaver Local (OH) | 48 | East Liverpool (OH) (3) | 0 | Hx 683 | |
| 2021-09-17 | H | W | Beaver Local (OH) | 27 | Edison Local (OH) (6) | 21 | Hx 684 | |
| 2021-09-24 | H | W | Beaver Local (OH) | 47 | Lutheran East (OH) (0) | 16 | Hx 1168 | |
| 2021-10-01 | H | W | Beaver Local (OH) | 48 | Harrison Central (OH) (1) | 14 | Hx 685 | |
| 2021-10-08 | A | W | Beaver Local (OH) | 41 | Indian Creek (OH) (0) | 7 | Hx 686 | |
| 2021-10-15 | H | W | Beaver Local (OH) | 44 | Martins Ferry (OH) (1) | 18 | Hx 687 | |
| 2021-10-22 | A | L | Beaver Local (OH) | 7 | Wheeling Central (9) | 21 | Hx 457 |