| Date | H/A | W/L | Team | Score | Opponent | Score | ||
| 2021-08-20 | A | L | Indian Creek (OH) | 7 | Cambridge (OH) (3) | 27 | Hx 724 | |
| 2021-08-27 | A | L | Indian Creek (OH) | 14 | East Liverpool (OH) (3) | 35 | Hx 701 | |
| 2021-09-02 | H | L | Indian Creek (OH) | 13 | Brooke (3) | 28 | Hx 30 | |
| 2021-09-10 | A | L | Indian Creek (OH) | 13 | Weir (2) | 19 | Hx 372 | |
| 2021-09-24 | H | L | Indian Creek (OH) | 19 | Bellaire (OH) (9) | 41 | Hx 673 | |
| 2021-10-01 | H | W | Indian Creek (OH) | 26 | Martins Ferry (OH) (1) | 14 | Hx 726 | |
| 2021-10-08 | H | L | Indian Creek (OH) | 7 | Beaver Local (OH) (3) | 41 | Hx 686 | |
| 2021-10-15 | A | L | Indian Creek (OH) | 23 | Harrison Central (OH) (1) | 33 | Hx 727 | |
| 2021-10-22 | A | L | Indian Creek (OH) | 7 | Edison Local (OH) (6) | 12 | Hx 728 |