| Date | H/A | W/L | Team | Score | Opponent | Score | ||
| 2021-08-28 | H | W | Fort Frye (OH) | 16 | St. Henry (OH) (0) | 12 | Hx 892 | |
| 2021-09-03 | A | W | Fort Frye (OH) | 39 | Waterford (OH) (6) | 14 | Hx 706 | |
| 2021-09-10 | A | W | Fort Frye (OH) | 26 | Zanesville (OH) (0) | 13 | Hx 707 | |
| 2021-09-17 | H | W | Fort Frye (OH) | 33 | Warren Local (OH) (1) | 7 | Hx 708 | |
| 2021-09-24 | A | W | Fort Frye (OH) | 45 | Trimble (OH) (7) | 13 | Hx 709 | |
| 2021-10-01 | A | L | Fort Frye (OH) | 23 | Lima Central Catholic (OH) (1) | 30 | Hx 893 | |
| 2021-10-15 | H | W | Fort Frye (OH) | 49 | Logan (OH) (0) | 14 | Hx 711 | |
| 2021-10-22 | A | W | Fort Frye (OH) | 41 | Williamstown (11) | 9 | Hx 460 |