| Date | H/A | W/L | Team | Score | Opponent | Score | ||
| 2021-08-20 | H | W | Warren Local (OH) | 47 | Belpre (OH) (1) | 12 | Hx 854 | |
| 2021-08-27 | A | L | Warren Local (OH) | 14 | Morgan (OH) (1) | 28 | Hx 855 | |
| 2021-09-04 | H | L | Warren Local (OH) | 6 | Williamstown (11) | 34 | Hx 459 | |
| 2021-09-10 | H | W | Warren Local (OH) | 54 | River (OH) (6) | 24 | Hx 1157 | |
| 2021-09-17 | A | L | Warren Local (OH) | 7 | Fort Frye (OH) (7) | 33 | Hx 708 | |
| 2021-09-24 | H | L | Warren Local (OH) | 7 | Dover (OH) (4) | 49 | Hx 857 | |
| 2021-10-01 | A | W | Warren Local (OH) | 28 | Vinton County (OH) (0) | 12 | Hx 858 | |
| 2021-10-08 | H | L | Warren Local (OH) | 10 | Cambridge (OH) (3) | 42 | Hx 859 | |
| 2021-10-15 | A | L | Warren Local (OH) | 7 | New Philadelphia (OH) (1) | 31 | Hx 860 | |
| 2021-10-22 | A | L | Warren Local (OH) | 0 | Marietta (OH) (1) | 20 | Hx 753 |