| Date | H/A | W/L | Team | Score | Opponent | Score | ||
| 2021-08-20 | A | W | Waterford (OH) | 29 | Crooksville (OH) (0) | 7 | Hx 849 | |
| 2021-08-27 | A | W | Waterford (OH) | 18 | Williamstown (11) | 12 | 2 OT Hx 458 | |
| 2021-09-03 | H | L | Waterford (OH) | 14 | Fort Frye (OH) (7) | 39 | Hx 706 | |
| 2021-09-11 | H | L | Waterford (OH) | 7 | Trimble (OH) (7) | 34 | Hx 832 | |
| 2021-09-24 | A | W | Waterford (OH) | 32 | Reedsville Eastern (OH) (4) | 0 | Hx 786 | |
| 2021-10-01 | A | W | Waterford (OH) | 55 | Racine Southern (OH) (4) | 0 | Hx 781 | |
| 2021-10-08 | H | W | Waterford (OH) | 14 | Shenandoah (OH) (1) | 6 | Hx 851 | |
| 2021-10-15 | H | L | Waterford (OH) | 14 | Caldwell (OH) (4) | 27 | Hx 852 | |
| 2021-10-22 | A | W | Waterford (OH) | 55 | Belpre (OH) (1) | 8 | Hx 853 |