| Date | H/A | W/L | Team | Score | Opponent | Score | ||
| 2021-08-21 | H | W | Trimble (OH) | 7 | Nelsonville-York (OH) (0) | 6 | Hx 829 | |
| 2021-08-27 | A | W | Trimble (OH) | 68 | Miller (OH) (2) | 0 | Hx 830 | |
| 2021-09-11 | A | W | Trimble (OH) | 34 | Waterford (OH) (6) | 7 | Hx 832 | |
| 2021-09-17 | A | L | Trimble (OH) | 33 | John Marshall (3) | 34 | Hx 120 | |
| 2021-09-24 | H | L | Trimble (OH) | 13 | Fort Frye (OH) (7) | 45 | Hx 709 | |
| 2021-10-01 | H | W | Trimble (OH) | 40 | South Gallia (OH) (0) | 0 | Hx 834 | |
| 2021-10-08 | A | W | Trimble (OH) | 57 | Belpre (OH) (1) | 8 | Hx 833 | |
| 2021-10-15 | H | W | Trimble (OH) | 34 | Racine Southern (OH) (4) | 0 | Hx 779 | |
| 2021-10-22 | H | W | Trimble (OH) | 55 | Crooksville (OH) (0) | 0 | Hx 1238 |