| Date | H/A | W/L | Team | Score | Opponent | Score | ||
| 2021-09-03 | H | W | Trinity | 28 | Bridgeport (OH) () | 14 | 440 | |
| 2021-09-24 | A | W | Trinity | 30 | Racine Southern (OH) () | 0 | 442 | |
| 2021-10-01 | H | L | Trinity | 13 | Cameron () | 22 | 569 | |
| 2021-10-06 | A | W | Trinity | 1 | Paden City () | 0 | 588 | |
| 2021-10-08 | A | W | Trinity | 63 | Hundred () | 0 | 1125 | |
| 2021-10-15 | A | W | Trinity | 53 | Hancock (MD) () | 0 | 443 | |
| 2021-10-22 | H | W | Trinity | 21 | Tygarts Valley () | 14 | 570 | |
| 2021-10-29 | A | L | Trinity | 0 | Cameron () | 30 | 485 | |
| 2021-11-05 | H | W | Trinity | 31 | Madonna () | 14 | 540 | |
| 2021-11-13 | A | L | Trinity | 0 | James Monroe () | 32 | 7-10 1st RD | 1269 |